C-type lectins are a family of glycoproteins that exhibit amino acid sequence similarities in their carbohydrate recognition domain (CRD) and that bind to selected carbohydrates in a Ca2+ -dependent manner. CLR s recognise carbohydrate profiles on microorganisms.DCs express a range of C-type lectins that either contains a single (type II) CRD or multiple CRDs (type I).
Drickamer K., J.Biol.Chem. 1988, 263, 9557; Weis W.I., et al.,1998, Immunol. rev., 163,19-34; Figdor CG. et al., Nature Reviews, 2002, 2,77-; Ebner S. et al.,2004 International Immunology, 16, 877-
|
Antigen
|
clone
|
main application
|
catalogue reference
|
| Langerin /CD207 |
808E10.01
817G7
DCGM4/122D5.03
929F3.01
306G9.01/HD24
310F7.02/HD26
|
HIV blocking
HIV blocking
Receptor internalization
IHC multispecies
IHC on mouse
Bouin paraffin
|
DDX0360
DDX0377
DDX0363
DDX0362
DDX0368
DDX0361
|
| CD303 /DLEC/BDCA-2 |
108H10.03
104C12.08
110H7.05
124B3.13
109B8.10
|
killing pDCs
Bouin/formol paraffin
killing pDCs
formol paraffin
Inhibition of IFN alpha
secretion
|
DDX0040
DDX0041
DDX0042
DDX0043
DDX0045
|
| DCIR DC immunoreceptor |
111F8.04 |
|
DDX0180
|
|
ASGPR /CD301
asialoglycoprotein receptor
|
125A10.03
121A5.01
|
Receptor internalization
|
DDX0010
DDX0011
|
| Mannose receptor /CD206 |
122D2.08 |
Receptor internalization
|
DDX0380
|
|
DC-SIGN/CD209
Dendritic Cell specific ICAM-3-grabbing non integrin
|
102E11.06
108C7.01
120C11.01
|
HIV gp120 blocking , surface FC
|
DDX0202
DDX0204
DDX0208
|
| DC-SIGN like |
118A8.05
128.G8.43
|
Receptor internalization
|
DDX0200
DDX0201
|
|
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