The ability to migrate is a central feature of DCs and indispensable for their functions within the immune system. Immature DCs express many receptors for "inflammatory"  chemokines such as MIP-3alpha/CCL20 produced by epithelial cells. In addition, non-chemotactic molecules promote or inhibit DC migration as matrix metalloproteinase (MMPs).Cavanagh L.L., et al.2002 Immunol Cell Biology, 80, 448.; Randolph GJ. et al., 2008, Nat.Rev.Immunol, 26, 293-.

DENDRITICS offers several and different clones for ImmunoChemistry and ELISA dendritic cell migration studies.

MIP3alpha/CCL20	Application		catalogue reference
clone 308B7.06	IHC:Bouin paraffin  embedded	human tonsil  paraffin section	DDX0431
clone 319F6.06	ELISA capture		DDX0430
clone 206D9.05	ELISA detection blocking migration		DDX0420
MMP12 /HME	Application
clone 603E6.22	IHC, ELISA		DDX0280
clone 706F9.01	ELISA detection		DDX0281
clone 701E4.03	ELISA capture,IP		DDX0284
clone 705D10.11	ELISA capture, IP, IHC		DDX0282